Conolidine’s analgesic outcomes stem from its conversation with non-opioid pain pathways. Compared with opioids, which bind to µ-opioid receptors in the central nervous technique, conolidine modulates alternate molecular targets. A Science Innovations analyze observed that conolidine interacts With all the atypical chemokine receptor ACKR3/CXCR7… Read More


Elucidating the specific pharmacological mechanism of motion (MOA) of naturally taking place compounds might be tough. Though Tarselli et al. (60) produced the initial de novo synthetic pathway to conolidine and showcased that this naturally developing compound properly suppresses responses to equally chemically induced and inflammation-derived pai… Read More